Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease. A MoCA ® nonimpaired group (MoCA ®-) was defined at sum-score > 25. Pani A., Mandas A., Diaz G., Abete C., Cocco P.L., Angius F., Brundu A., Muçaka N., Pais M.E., Saba A., et al. Assessing the Preparedness of the Health Care System Infrastructure in Six European Countries for an Alzheimer’s Treatment. The MoCA has been shown to be more sensitive than the MMSE for the detection of MCI and mild AD in the general population, and a score 25 was found to be the optimal cutoff point for a diagnosis of cognitive impairment. Nutritional Status and Potentially Inappropriate Medications in Elderly. Loddo S., Salis F., Rundeddu S., Serchisu L., Peralta M.M., Mandas A. Anemia in Elderly Patients-The Impact of Hemoglobin Cut-Off Levels on Geriatric Domains. Alzheimer’s Disease International London, UK: 2019. World Alzheimer Report 2019: Attitudes to Dementia. La cotation de l’évaluation se fait directement sur la grille et simultanément à la passation. As older adults represent the majority of patients who have cognitive screening performed for symptoms of memory loss, the Qmci may be a shorter and more accurate alternative, especially when used with a higher cut-off score. Mini-Mental State Examination (MMSE) Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) dementia memory mild cognitive impairment (MCI) screening.Īlzheimer’s Disease International. Though different cut-offs are needed to discriminate different impairment degrees, the 26.1-point score seems to be preferable to the others. The study shows that the MMSE does not identify early cognitive impairment. The cut-off point for mild impairment in our sample is one point lower than that obtained by Nasreddine and colleagues who developed the MoCA for a population with mild cognitive impairment (Nasreddine et al., 2005) but is analogous to other research findings suggesting lower cut-off scores than the standard one for dementia (Damian et al. The total possible score is 30 points a score of 26 or above is considered normal. Time to administer the MoCA is approximately 10 minutes. Our research examining the MoCA and MMSE stratified by age and education confirmed an optimal general cutoff score for cognitive screening. Youden's J indexes were used to consider the better sensitivity/specificity balance in the 24-point cut-off score for severe cognitive deficit, 29.7-point score for mild cognitive deficit, and 26.1-point score for both mild and severe cognitive deficit. The MoCA may be administered by anyone who understands and follows the instructions, however, only a health professional with expertise in the cognitive field may interpret the results. We used RBANS as a categorial variable to identify different degrees of cognitive impairment. The two tests (MMSE and RBANS) showed a moderate correlation in identifying cognitive deficit. No significant gender-related differences in cognitive ability were identified. The sample consisted of 262 participants with mean age 73.8 years (60-87), of whom 154 (58.8%) women.
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We studied a population of 262 patients referred for cognitive impairment testing using the MMSE and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a neuropsychological battery. Here, we propose differential cut-off levels that can be used to identify mild and severe cognitive impairment with a simple and widely used first-level neurocognitive screening test: the Mini-Mental State Examination (MMSE). Given considerable heterogeneity in cognitive performance on screening measures across diverse populations (e.g., ethnic/racial, education, income, geographic), the findings support continued research into the use of culturally and educationally agnostic, globally applicable, metrics to aid in accurate early detection of cognitive impairment.Considering the need to intercept neurocognitive damage as soon as possible, it would be useful to extend cognitive test screening throughout the population. The limitations of this study include a highly educated, primarily non-Hispanic, white population that hails from the same geographic region. Findings are comparatively more consistent with the recently suggested MCI cutoff score of 23 and highlight the need for population- based norms when using the MoCA. Findings also suggest that the original cutoff score of 26 on the MoCA is likely too high and can potentially result in a high false positive rate for MCI within a healthy sample, especially given the low delayed recall score irrespective of age. Several validation studies have been conducted on the MoCA, in a variety of clinical populations. Results indicate that MoCA scores decrease with increasing age and education. The Montreal Cognitive Assessment (MoCA Nasreddine et al., 2005) is a cognitive screening tool that aims to differentiate healthy cognitive aging from Mild Cognitive Impairment (MCI).